Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis
Identifieur interne : 000397 ( Main/Exploration ); précédent : 000396; suivant : 000398Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis
Auteurs : Michael A. Van Es [Pays-Bas] ; Helenius J. Schelhaas [Pays-Bas] ; Paul W. J. Van Vught [Pays-Bas] ; Nicola Ticozzi [États-Unis, Italie] ; Peter M. Andersen [Suède] ; Ewout J. N. Groen [Pays-Bas] ; Claudia Schulte [Allemagne] ; Hylke M. Blauw [Pays-Bas] ; Max Koppers [Pays-Bas] ; Frank P. Diekstra [Pays-Bas] ; Katsumi Fumoto [Pays-Bas] ; Ashley Lyn Leclerc [États-Unis] ; Pamela Keagle [États-Unis] ; Bastiaan R. Bloem [Pays-Bas] ; Hans Scheffer [Pays-Bas] ; Bart F. L. Van Nuenen [Pays-Bas] ; Marka Van Blitterswijk [Pays-Bas] ; Wouter Van Rheenen [Pays-Bas] ; Anne-Marie Wills [États-Unis] ; Patrick P. Lowe [États-Unis] ; Guo-Fu Hu [États-Unis] ; Wenhao Yu [États-Unis] ; Hiroko Kishikawa [États-Unis] ; David Wu [États-Unis] ; Rebecca D. Folkerth [États-Unis] ; Claudio Mariani [Italie] ; Stefano Goldwurm [Italie] ; Gianni Pezzoli [Italie] ; Philip Van Damme [Belgique] ; Robin Lemmens [Belgique] ; Caroline Dahlberg [Suède] ; Anna Birve [Suède] ; Rubén Fernández-Santiago [Pays-Bas, Espagne, Allemagne] ; Stefan Waibel [Allemagne] ; Christine Klein [Allemagne] ; Markus Weber [Suisse] ; Anneke J. Van Der Kooi [Pays-Bas] ; Marianne De Visser [Pays-Bas] ; Dagmar Verbaan [Pays-Bas] ; Jacobus J. Van Hilten [Pays-Bas] ; Peter Heutink [Pays-Bas] ; Eric A. M. Hennekam [Pays-Bas] ; Edwin Cuppen [Pays-Bas] ; Daniela Berg [Pays-Bas] ; Robert H. Brown Jr [États-Unis] ; Vincenzo Silani [Italie] ; Thomas Gasser [Allemagne] ; Albert C. Ludolph [Allemagne] ; Wim Robberecht [Belgique] ; Roel A. Ophoff [Pays-Bas, États-Unis] ; Jan H. Veldink [Pays-Bas] ; R. Jeroen Pasterkamp [Pays-Bas] ; Paul I. W. De Bakker [Pays-Bas, États-Unis] ; John E. Landers [États-Unis] ; Bart P. Van De Warrenburg [Pays-Bas] ; Leonard H. Van Den Berg [Pays-Bas]Source :
- Annals of Neurology [ 0364-5134 ] ; 2011-12.
Abstract
Objective:: Several studies have suggested an increased frequency of variants in the gene encoding angiogenin (ANG) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, a few ALS patients carrying ANG variants also showed signs of Parkinson disease (PD). Furthermore, relatives of ALS patients have an increased risk to develop PD, and the prevalence of concomitant motor neuron disease in PD is higher than expected based on chance occurrence. We therefore investigated whether ANG variants could predispose to both ALS and PD. Methods:: We reviewed all previous studies on ANG in ALS and performed sequence experiments on additional samples, which allowed us to analyze data from 6,471 ALS patients and 7,668 controls from 15 centers (13 from Europe and 2 from the USA). We sequenced DNA samples from 3,146 PD patients from 6 centers (5 from Europe and 1 from the USA). Statistical analysis was performed using the variable threshold test, and the Mantel‐Haenszel procedure was used to estimate odds ratios. Results:: Analysis of sequence data from 17,258 individuals demonstrated a significantly higher frequency of ANG variants in both ALS and PD patients compared to control subjects (p = 9.3 × 10−6 for ALS and p = 4.3 × 10−5 for PD). The odds ratio for any ANG variant in patients versus controls was 9.2 for ALS and 6.7 for PD. Interpretation:: The data from this multicenter study demonstrate that there is a strong association between PD, ALS, and ANG variants. ANG is a genetic link between ALS and PD. ANN NEUROL 2011;70:964–973
Url:
DOI: 10.1002/ana.22611
Affiliations:
- Allemagne, Belgique, Espagne, Italie, Pays-Bas, Suisse, Suède, États-Unis
- Bade-Wurtemberg, Californie, Catalogne, District de Tübingen, Gueldre, Hollande-Méridionale, Hollande-Septentrionale, Lombardie, Massachusetts, Utrecht (province)
- Amsterdam, Barcelone, Leyde, Milan, Nimègue, Tübingen, Ulm, Utrecht
- Université d'Ulm
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis</title><author><name sortKey="Van Es, Michael A" sort="Van Es, Michael A" uniqKey="Van Es M" first="Michael A." last="Van Es">Michael A. Van Es</name></author><author><name sortKey="Schelhaas, Helenius J" sort="Schelhaas, Helenius J" uniqKey="Schelhaas H" first="Helenius J." last="Schelhaas">Helenius J. Schelhaas</name></author><author><name sortKey="Van Vught, Paul W J" sort="Van Vught, Paul W J" uniqKey="Van Vught P" first="Paul W. J." last="Van Vught">Paul W. J. Van Vught</name></author><author><name sortKey="Ticozzi, Nicola" sort="Ticozzi, Nicola" uniqKey="Ticozzi N" first="Nicola" last="Ticozzi">Nicola Ticozzi</name></author><author><name sortKey="Andersen, Peter M" sort="Andersen, Peter M" uniqKey="Andersen P" first="Peter M." last="Andersen">Peter M. Andersen</name></author><author><name sortKey="Groen, Ewout J N" sort="Groen, Ewout J N" uniqKey="Groen E" first="Ewout J. N." last="Groen">Ewout J. N. Groen</name></author><author><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name></author><author><name sortKey="Blauw, Hylke M" sort="Blauw, Hylke M" uniqKey="Blauw H" first="Hylke M." last="Blauw">Hylke M. Blauw</name></author><author><name sortKey="Koppers, Max" sort="Koppers, Max" uniqKey="Koppers M" first="Max" last="Koppers">Max Koppers</name></author><author><name sortKey="Diekstra, Frank P" sort="Diekstra, Frank P" uniqKey="Diekstra F" first="Frank P." last="Diekstra">Frank P. Diekstra</name></author><author><name sortKey="Fumoto, Katsumi" sort="Fumoto, Katsumi" uniqKey="Fumoto K" first="Katsumi" last="Fumoto">Katsumi Fumoto</name></author><author><name sortKey="Leclerc, Ashley Lyn" sort="Leclerc, Ashley Lyn" uniqKey="Leclerc A" first="Ashley Lyn" last="Leclerc">Ashley Lyn Leclerc</name></author><author><name sortKey="Keagle, Pamela" sort="Keagle, Pamela" uniqKey="Keagle P" first="Pamela" last="Keagle">Pamela Keagle</name></author><author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R." last="Bloem">Bastiaan R. Bloem</name></author><author><name sortKey="Scheffer, Hans" sort="Scheffer, Hans" uniqKey="Scheffer H" first="Hans" last="Scheffer">Hans Scheffer</name></author><author><name sortKey="Van Nuenen, Bart F L" sort="Van Nuenen, Bart F L" uniqKey="Van Nuenen B" first="Bart F. L." last="Van Nuenen">Bart F. L. Van Nuenen</name></author><author><name sortKey="Van Blitterswijk, Marka" sort="Van Blitterswijk, Marka" uniqKey="Van Blitterswijk M" first="Marka" last="Van Blitterswijk">Marka Van Blitterswijk</name></author><author><name sortKey="Van Rheenen, Wouter" sort="Van Rheenen, Wouter" uniqKey="Van Rheenen W" first="Wouter" last="Van Rheenen">Wouter Van Rheenen</name></author><author><name sortKey="Wills, Anne Arie" sort="Wills, Anne Arie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name></author><author><name sortKey="Lowe, Patrick P" sort="Lowe, Patrick P" uniqKey="Lowe P" first="Patrick P." last="Lowe">Patrick P. Lowe</name></author><author><name sortKey="Hu, Guo U" sort="Hu, Guo U" uniqKey="Hu G" first="Guo-Fu" last="Hu">Guo-Fu Hu</name></author><author><name sortKey="Yu, Wenhao" sort="Yu, Wenhao" uniqKey="Yu W" first="Wenhao" last="Yu">Wenhao Yu</name></author><author><name sortKey="Kishikawa, Hiroko" sort="Kishikawa, Hiroko" uniqKey="Kishikawa H" first="Hiroko" last="Kishikawa">Hiroko Kishikawa</name></author><author><name sortKey="Wu, David" sort="Wu, David" uniqKey="Wu D" first="David" last="Wu">David Wu</name></author><author><name sortKey="Folkerth, Rebecca D" sort="Folkerth, Rebecca D" uniqKey="Folkerth R" first="Rebecca D." last="Folkerth">Rebecca D. Folkerth</name></author><author><name sortKey="Mariani, Claudio" sort="Mariani, Claudio" uniqKey="Mariani C" first="Claudio" last="Mariani">Claudio Mariani</name></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name></author><author><name sortKey="Van Damme, Philip" sort="Van Damme, Philip" uniqKey="Van Damme P" first="Philip" last="Van Damme">Philip Van Damme</name></author><author><name sortKey="Lemmens, Robin" sort="Lemmens, Robin" uniqKey="Lemmens R" first="Robin" last="Lemmens">Robin Lemmens</name></author><author><name sortKey="Dahlberg, Caroline" sort="Dahlberg, Caroline" uniqKey="Dahlberg C" first="Caroline" last="Dahlberg">Caroline Dahlberg</name></author><author><name sortKey="Birve, Anna" sort="Birve, Anna" uniqKey="Birve A" first="Anna" last="Birve">Anna Birve</name></author><author><name sortKey="Fernandez Antiago, Ruben" sort="Fernandez Antiago, Ruben" uniqKey="Fernandez Antiago R" first="Rubén" last="Fernández-Santiago">Rubén Fernández-Santiago</name></author><author><name sortKey="Waibel, Stefan" sort="Waibel, Stefan" uniqKey="Waibel S" first="Stefan" last="Waibel">Stefan Waibel</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Weber, Markus" sort="Weber, Markus" uniqKey="Weber M" first="Markus" last="Weber">Markus Weber</name></author><author><name sortKey="Van Der Kooi, Anneke J" sort="Van Der Kooi, Anneke J" uniqKey="Van Der Kooi A" first="Anneke J." last="Van Der Kooi">Anneke J. Van Der Kooi</name></author><author><name sortKey="De Visser, Marianne" sort="De Visser, Marianne" uniqKey="De Visser M" first="Marianne" last="De Visser">Marianne De Visser</name></author><author><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name></author><author><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J." last="Van Hilten">Jacobus J. Van Hilten</name></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name></author><author><name sortKey="Hennekam, Eric A M" sort="Hennekam, Eric A M" uniqKey="Hennekam E" first="Eric A. M." last="Hennekam">Eric A. M. Hennekam</name></author><author><name sortKey="Cuppen, Edwin" sort="Cuppen, Edwin" uniqKey="Cuppen E" first="Edwin" last="Cuppen">Edwin Cuppen</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author><author><name sortKey="Brown Jr, Robert H" sort="Brown Jr, Robert H" uniqKey="Brown Jr R" first="Robert H." last="Brown Jr">Robert H. Brown Jr</name></author><author><name sortKey="Silani, Vincenzo" sort="Silani, Vincenzo" uniqKey="Silani V" first="Vincenzo" last="Silani">Vincenzo Silani</name></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name></author><author><name sortKey="Robberecht, Wim" sort="Robberecht, Wim" uniqKey="Robberecht W" first="Wim" last="Robberecht">Wim Robberecht</name></author><author><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A." last="Ophoff">Roel A. Ophoff</name></author><author><name sortKey="Veldink, Jan H" sort="Veldink, Jan H" uniqKey="Veldink J" first="Jan H." last="Veldink">Jan H. Veldink</name></author><author><name sortKey="Pasterkamp, R Jeroen" sort="Pasterkamp, R Jeroen" uniqKey="Pasterkamp R" first="R. Jeroen" last="Pasterkamp">R. Jeroen Pasterkamp</name></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name></author><author><name sortKey="Landers, John E" sort="Landers, John E" uniqKey="Landers J" first="John E." last="Landers">John E. Landers</name></author><author><name sortKey="Van De Warrenburg, Bart P" sort="Van De Warrenburg, Bart P" uniqKey="Van De Warrenburg B" first="Bart P." last="Van De Warrenburg">Bart P. Van De Warrenburg</name></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1104402D2CD5B78610B101FB2326A7D93EC038A3</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/ana.22611</idno><idno type="url">https://api.istex.fr/document/1104402D2CD5B78610B101FB2326A7D93EC038A3/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000768</idno><idno type="wicri:Area/Main/Curation">000670</idno><idno type="wicri:Area/Main/Exploration">000397</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis</title><author><name sortKey="Van Es, Michael A" sort="Van Es, Michael A" uniqKey="Van Es M" first="Michael A." last="Van Es">Michael A. Van Es</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Schelhaas, Helenius J" sort="Schelhaas, Helenius J" uniqKey="Schelhaas H" first="Helenius J." last="Schelhaas">Helenius J. Schelhaas</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Donders Instute for Brain, Cognition, and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Van Vught, Paul W J" sort="Van Vught, Paul W J" uniqKey="Van Vught P" first="Paul W. J." last="Van Vught">Paul W. J. Van Vught</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Ticozzi, Nicola" sort="Ticozzi, Nicola" uniqKey="Ticozzi N" first="Nicola" last="Ticozzi">Nicola Ticozzi</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, University of Massachusetts Medical School, Worcester</wicri:cityArea></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Andersen, Peter M" sort="Andersen, Peter M" uniqKey="Andersen P" first="Peter M." last="Andersen">Peter M. Andersen</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Clinical Neuroscience, Umeå University Hospital, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Groen, Ewout J N" sort="Groen, Ewout J N" uniqKey="Groen E" first="Ewout J. N." last="Groen">Ewout J. N. Groen</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Blauw, Hylke M" sort="Blauw, Hylke M" uniqKey="Blauw H" first="Hylke M." last="Blauw">Hylke M. Blauw</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Koppers, Max" sort="Koppers, Max" uniqKey="Koppers M" first="Max" last="Koppers">Max Koppers</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Diekstra, Frank P" sort="Diekstra, Frank P" uniqKey="Diekstra F" first="Frank P." last="Diekstra">Frank P. Diekstra</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Fumoto, Katsumi" sort="Fumoto, Katsumi" uniqKey="Fumoto K" first="Katsumi" last="Fumoto">Katsumi Fumoto</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Leclerc, Ashley Lyn" sort="Leclerc, Ashley Lyn" uniqKey="Leclerc A" first="Ashley Lyn" last="Leclerc">Ashley Lyn Leclerc</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, University of Massachusetts Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Keagle, Pamela" sort="Keagle, Pamela" uniqKey="Keagle P" first="Pamela" last="Keagle">Pamela Keagle</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, University of Massachusetts Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R." last="Bloem">Bastiaan R. Bloem</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Donders Instute for Brain, Cognition, and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Scheffer, Hans" sort="Scheffer, Hans" uniqKey="Scheffer H" first="Hans" last="Scheffer">Hans Scheffer</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Van Nuenen, Bart F L" sort="Van Nuenen, Bart F L" uniqKey="Van Nuenen B" first="Bart F. L." last="Van Nuenen">Bart F. L. Van Nuenen</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Donders Instute for Brain, Cognition, and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Van Blitterswijk, Marka" sort="Van Blitterswijk, Marka" uniqKey="Van Blitterswijk M" first="Marka" last="Van Blitterswijk">Marka Van Blitterswijk</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Van Rheenen, Wouter" sort="Van Rheenen, Wouter" uniqKey="Van Rheenen W" first="Wouter" last="Van Rheenen">Wouter Van Rheenen</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Wills, Anne Arie" sort="Wills, Anne Arie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Lowe, Patrick P" sort="Lowe, Patrick P" uniqKey="Lowe P" first="Patrick P." last="Lowe">Patrick P. Lowe</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, University of Massachusetts Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Hu, Guo U" sort="Hu, Guo U" uniqKey="Hu G" first="Guo-Fu" last="Hu">Guo-Fu Hu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Wenhao" sort="Yu, Wenhao" uniqKey="Yu W" first="Wenhao" last="Yu">Wenhao Yu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Kishikawa, Hiroko" sort="Kishikawa, Hiroko" uniqKey="Kishikawa H" first="Hiroko" last="Kishikawa">Hiroko Kishikawa</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Wu, David" sort="Wu, David" uniqKey="Wu D" first="David" last="Wu">David Wu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Folkerth, Rebecca D" sort="Folkerth, Rebecca D" uniqKey="Folkerth R" first="Rebecca D." last="Folkerth">Rebecca D. Folkerth</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Mariani, Claudio" sort="Mariani, Claudio" uniqKey="Mariani C" first="Claudio" last="Mariani">Claudio Mariani</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Van Damme, Philip" sort="Van Damme, Philip" uniqKey="Van Damme P" first="Philip" last="Van Damme">Philip Van Damme</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Experimental Neurology, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center, Flanders Institute for Biotechnology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, University Hospital Leuven, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Lemmens, Robin" sort="Lemmens, Robin" uniqKey="Lemmens R" first="Robin" last="Lemmens">Robin Lemmens</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Experimental Neurology, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center, Flanders Institute for Biotechnology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, University Hospital Leuven, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Dahlberg, Caroline" sort="Dahlberg, Caroline" uniqKey="Dahlberg C" first="Caroline" last="Dahlberg">Caroline Dahlberg</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Clinical Neuroscience, Umeå University Hospital, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Birve, Anna" sort="Birve, Anna" uniqKey="Birve A" first="Anna" last="Birve">Anna Birve</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Clinical Neuroscience, Umeå University Hospital, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Antiago, Ruben" sort="Fernandez Antiago, Ruben" uniqKey="Fernandez Antiago R" first="Rubén" last="Fernández-Santiago">Rubén Fernández-Santiago</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department for Clinical and Experimental Neurology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Graduate School of Cellular and Molecular Neuroscience, International Max Planck Research School, Graduate Training Center of Neuroscience, Eberhard‐Karls University, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Waibel, Stefan" sort="Waibel, Stefan" uniqKey="Waibel S" first="Stefan" last="Waibel">Stefan Waibel</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Markus" sort="Weber, Markus" uniqKey="Weber M" first="Markus" last="Weber">Markus Weber</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Neuromuscular Diseases Unit, Kantonspital St Gallen, St Gallen</wicri:regionArea><wicri:noRegion>St Gallen</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Kooi, Anneke J" sort="Van Der Kooi, Anneke J" uniqKey="Van Der Kooi A" first="Anneke J." last="Van Der Kooi">Anneke J. Van Der Kooi</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Amsterdam Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="De Visser, Marianne" sort="De Visser, Marianne" uniqKey="De Visser M" first="Marianne" last="De Visser">Marianne De Visser</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Amsterdam Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J." last="Van Hilten">Jacobus J. Van Hilten</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hennekam, Eric A M" sort="Hennekam, Eric A M" uniqKey="Hennekam E" first="Eric A. M." last="Hennekam">Eric A. M. Hennekam</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Cuppen, Edwin" sort="Cuppen, Edwin" uniqKey="Cuppen E" first="Edwin" last="Cuppen">Edwin Cuppen</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Hubrecht Institute for Developmental Biology and Stem Cell Research, Cancer Genomics Center, Royal Netherlands Academy of Sciences, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Brown Jr, Robert H" sort="Brown Jr, Robert H" uniqKey="Brown Jr R" first="Robert H." last="Brown Jr">Robert H. Brown Jr</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, University of Massachusetts Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Silani, Vincenzo" sort="Silani, Vincenzo" uniqKey="Silani V" first="Vincenzo" last="Silani">Vincenzo Silani</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Milan Medical School, “Dino Ferrari” Center, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Robberecht, Wim" sort="Robberecht, Wim" uniqKey="Robberecht W" first="Wim" last="Robberecht">Wim Robberecht</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Experimental Neurology, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center, Flanders Institute for Biotechnology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, University Hospital Leuven, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A." last="Ophoff">Roel A. Ophoff</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of California at Los Angeles Center for Neurobehavioral Genetics, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Veldink, Jan H" sort="Veldink, Jan H" uniqKey="Veldink J" first="Jan H." last="Veldink">Jan H. Veldink</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Pasterkamp, R Jeroen" sort="Pasterkamp, R Jeroen" uniqKey="Pasterkamp R" first="R. Jeroen" last="Pasterkamp">R. Jeroen Pasterkamp</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Landers, John E" sort="Landers, John E" uniqKey="Landers J" first="John E." last="Landers">John E. Landers</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, University of Massachusetts Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P" sort="Van De Warrenburg, Bart P" uniqKey="Van De Warrenburg B" first="Bart P." last="Van De Warrenburg">Bart P. Van De Warrenburg</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Donders Instute for Brain, Cognition, and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Bart P. van de Warrenburg, Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Geert Grooteplein‐Zuid 10, 6525 GA Nijmegen, the NetherlandsLeonard H. van den Berg, Department of Neurology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea><wicri:noRegion>3584 CX Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Bart P. van de Warrenburg, Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Geert Grooteplein‐Zuid 10, 6525 GA Nijmegen, the NetherlandsLeonard H. van den Berg, Department of Neurology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea><wicri:noRegion>3584 CX Utrecht</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12">2011-12</date><biblScope unit="volume">70</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="964">964</biblScope><biblScope unit="page" to="973">973</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">1104402D2CD5B78610B101FB2326A7D93EC038A3</idno><idno type="DOI">10.1002/ana.22611</idno><idno type="ArticleID">ANA22611</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective:: Several studies have suggested an increased frequency of variants in the gene encoding angiogenin (ANG) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, a few ALS patients carrying ANG variants also showed signs of Parkinson disease (PD). Furthermore, relatives of ALS patients have an increased risk to develop PD, and the prevalence of concomitant motor neuron disease in PD is higher than expected based on chance occurrence. We therefore investigated whether ANG variants could predispose to both ALS and PD. Methods:: We reviewed all previous studies on ANG in ALS and performed sequence experiments on additional samples, which allowed us to analyze data from 6,471 ALS patients and 7,668 controls from 15 centers (13 from Europe and 2 from the USA). We sequenced DNA samples from 3,146 PD patients from 6 centers (5 from Europe and 1 from the USA). Statistical analysis was performed using the variable threshold test, and the Mantel‐Haenszel procedure was used to estimate odds ratios. Results:: Analysis of sequence data from 17,258 individuals demonstrated a significantly higher frequency of ANG variants in both ALS and PD patients compared to control subjects (p = 9.3 × 10−6 for ALS and p = 4.3 × 10−5 for PD). The odds ratio for any ANG variant in patients versus controls was 9.2 for ALS and 6.7 for PD. Interpretation:: The data from this multicenter study demonstrate that there is a strong association between PD, ALS, and ANG variants. ANG is a genetic link between ALS and PD. ANN NEUROL 2011;70:964–973</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li><li>Espagne</li><li>Italie</li><li>Pays-Bas</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Californie</li><li>Catalogne</li><li>District de Tübingen</li><li>Gueldre</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Lombardie</li><li>Massachusetts</li><li>Utrecht (province)</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Leyde</li><li>Milan</li><li>Nimègue</li><li>Tübingen</li><li>Ulm</li><li>Utrecht</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Van Es, Michael A" sort="Van Es, Michael A" uniqKey="Van Es M" first="Michael A." last="Van Es">Michael A. Van Es</name></noRegion><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Blauw, Hylke M" sort="Blauw, Hylke M" uniqKey="Blauw H" first="Hylke M." last="Blauw">Hylke M. Blauw</name><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R." last="Bloem">Bastiaan R. Bloem</name><name sortKey="Cuppen, Edwin" sort="Cuppen, Edwin" uniqKey="Cuppen E" first="Edwin" last="Cuppen">Edwin Cuppen</name><name sortKey="Cuppen, Edwin" sort="Cuppen, Edwin" uniqKey="Cuppen E" first="Edwin" last="Cuppen">Edwin Cuppen</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="De Visser, Marianne" sort="De Visser, Marianne" uniqKey="De Visser M" first="Marianne" last="De Visser">Marianne De Visser</name><name sortKey="Diekstra, Frank P" sort="Diekstra, Frank P" uniqKey="Diekstra F" first="Frank P." last="Diekstra">Frank P. Diekstra</name><name sortKey="Fernandez Antiago, Ruben" sort="Fernandez Antiago, Ruben" uniqKey="Fernandez Antiago R" first="Rubén" last="Fernández-Santiago">Rubén Fernández-Santiago</name><name sortKey="Fumoto, Katsumi" sort="Fumoto, Katsumi" uniqKey="Fumoto K" first="Katsumi" last="Fumoto">Katsumi Fumoto</name><name sortKey="Groen, Ewout J N" sort="Groen, Ewout J N" uniqKey="Groen E" first="Ewout J. N." last="Groen">Ewout J. N. Groen</name><name sortKey="Hennekam, Eric A M" sort="Hennekam, Eric A M" uniqKey="Hennekam E" first="Eric A. M." last="Hennekam">Eric A. M. Hennekam</name><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><name sortKey="Koppers, Max" sort="Koppers, Max" uniqKey="Koppers M" first="Max" last="Koppers">Max Koppers</name><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A." last="Ophoff">Roel A. Ophoff</name><name sortKey="Pasterkamp, R Jeroen" sort="Pasterkamp, R Jeroen" uniqKey="Pasterkamp R" first="R. Jeroen" last="Pasterkamp">R. Jeroen Pasterkamp</name><name sortKey="Scheffer, Hans" sort="Scheffer, Hans" uniqKey="Scheffer H" first="Hans" last="Scheffer">Hans Scheffer</name><name sortKey="Schelhaas, Helenius J" sort="Schelhaas, Helenius J" uniqKey="Schelhaas H" first="Helenius J." last="Schelhaas">Helenius J. Schelhaas</name><name sortKey="Van Blitterswijk, Marka" sort="Van Blitterswijk, Marka" uniqKey="Van Blitterswijk M" first="Marka" last="Van Blitterswijk">Marka Van Blitterswijk</name><name sortKey="Van De Warrenburg, Bart P" sort="Van De Warrenburg, Bart P" uniqKey="Van De Warrenburg B" first="Bart P." last="Van De Warrenburg">Bart P. Van De Warrenburg</name><name sortKey="Van De Warrenburg, Bart P" sort="Van De Warrenburg, Bart P" uniqKey="Van De Warrenburg B" first="Bart P." last="Van De Warrenburg">Bart P. Van De Warrenburg</name><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name><name sortKey="Van Der Kooi, Anneke J" sort="Van Der Kooi, Anneke J" uniqKey="Van Der Kooi A" first="Anneke J." last="Van Der Kooi">Anneke J. Van Der Kooi</name><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J." last="Van Hilten">Jacobus J. Van Hilten</name><name sortKey="Van Nuenen, Bart F L" sort="Van Nuenen, Bart F L" uniqKey="Van Nuenen B" first="Bart F. L." last="Van Nuenen">Bart F. L. Van Nuenen</name><name sortKey="Van Rheenen, Wouter" sort="Van Rheenen, Wouter" uniqKey="Van Rheenen W" first="Wouter" last="Van Rheenen">Wouter Van Rheenen</name><name sortKey="Van Vught, Paul W J" sort="Van Vught, Paul W J" uniqKey="Van Vught P" first="Paul W. J." last="Van Vught">Paul W. J. Van Vught</name><name sortKey="Veldink, Jan H" sort="Veldink, Jan H" uniqKey="Veldink J" first="Jan H." last="Veldink">Jan H. Veldink</name><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Ticozzi, Nicola" sort="Ticozzi, Nicola" uniqKey="Ticozzi N" first="Nicola" last="Ticozzi">Nicola Ticozzi</name></region><name sortKey="Brown Jr, Robert H" sort="Brown Jr, Robert H" uniqKey="Brown Jr R" first="Robert H." last="Brown Jr">Robert H. Brown Jr</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="Folkerth, Rebecca D" sort="Folkerth, Rebecca D" uniqKey="Folkerth R" first="Rebecca D." last="Folkerth">Rebecca D. Folkerth</name><name sortKey="Hu, Guo U" sort="Hu, Guo U" uniqKey="Hu G" first="Guo-Fu" last="Hu">Guo-Fu Hu</name><name sortKey="Keagle, Pamela" sort="Keagle, Pamela" uniqKey="Keagle P" first="Pamela" last="Keagle">Pamela Keagle</name><name sortKey="Kishikawa, Hiroko" sort="Kishikawa, Hiroko" uniqKey="Kishikawa H" first="Hiroko" last="Kishikawa">Hiroko Kishikawa</name><name sortKey="Landers, John E" sort="Landers, John E" uniqKey="Landers J" first="John E." last="Landers">John E. Landers</name><name sortKey="Leclerc, Ashley Lyn" sort="Leclerc, Ashley Lyn" uniqKey="Leclerc A" first="Ashley Lyn" last="Leclerc">Ashley Lyn Leclerc</name><name sortKey="Lowe, Patrick P" sort="Lowe, Patrick P" uniqKey="Lowe P" first="Patrick P." last="Lowe">Patrick P. Lowe</name><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A." last="Ophoff">Roel A. Ophoff</name><name sortKey="Wills, Anne Arie" sort="Wills, Anne Arie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name><name sortKey="Wu, David" sort="Wu, David" uniqKey="Wu D" first="David" last="Wu">David Wu</name><name sortKey="Yu, Wenhao" sort="Yu, Wenhao" uniqKey="Yu W" first="Wenhao" last="Yu">Wenhao Yu</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Ticozzi, Nicola" sort="Ticozzi, Nicola" uniqKey="Ticozzi N" first="Nicola" last="Ticozzi">Nicola Ticozzi</name></region><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><name sortKey="Mariani, Claudio" sort="Mariani, Claudio" uniqKey="Mariani C" first="Claudio" last="Mariani">Claudio Mariani</name><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><name sortKey="Silani, Vincenzo" sort="Silani, Vincenzo" uniqKey="Silani V" first="Vincenzo" last="Silani">Vincenzo Silani</name><name sortKey="Silani, Vincenzo" sort="Silani, Vincenzo" uniqKey="Silani V" first="Vincenzo" last="Silani">Vincenzo Silani</name></country><country name="Suède"><noRegion><name sortKey="Andersen, Peter M" sort="Andersen, Peter M" uniqKey="Andersen P" first="Peter M." last="Andersen">Peter M. Andersen</name></noRegion><name sortKey="Birve, Anna" sort="Birve, Anna" uniqKey="Birve A" first="Anna" last="Birve">Anna Birve</name><name sortKey="Dahlberg, Caroline" sort="Dahlberg, Caroline" uniqKey="Dahlberg C" first="Caroline" last="Dahlberg">Caroline Dahlberg</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name></region><name sortKey="Fernandez Antiago, Ruben" sort="Fernandez Antiago, Ruben" uniqKey="Fernandez Antiago R" first="Rubén" last="Fernández-Santiago">Rubén Fernández-Santiago</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name><name sortKey="Waibel, Stefan" sort="Waibel, Stefan" uniqKey="Waibel S" first="Stefan" last="Waibel">Stefan Waibel</name></country><country name="Belgique"><noRegion><name sortKey="Van Damme, Philip" sort="Van Damme, Philip" uniqKey="Van Damme P" first="Philip" last="Van Damme">Philip Van Damme</name></noRegion><name sortKey="Lemmens, Robin" sort="Lemmens, Robin" uniqKey="Lemmens R" first="Robin" last="Lemmens">Robin Lemmens</name><name sortKey="Lemmens, Robin" sort="Lemmens, Robin" uniqKey="Lemmens R" first="Robin" last="Lemmens">Robin Lemmens</name><name sortKey="Lemmens, Robin" sort="Lemmens, Robin" uniqKey="Lemmens R" first="Robin" last="Lemmens">Robin Lemmens</name><name sortKey="Robberecht, Wim" sort="Robberecht, Wim" uniqKey="Robberecht W" first="Wim" last="Robberecht">Wim Robberecht</name><name sortKey="Robberecht, Wim" sort="Robberecht, Wim" uniqKey="Robberecht W" first="Wim" last="Robberecht">Wim Robberecht</name><name sortKey="Robberecht, Wim" sort="Robberecht, Wim" uniqKey="Robberecht W" first="Wim" last="Robberecht">Wim Robberecht</name><name sortKey="Van Damme, Philip" sort="Van Damme, Philip" uniqKey="Van Damme P" first="Philip" last="Van Damme">Philip Van Damme</name><name sortKey="Van Damme, Philip" sort="Van Damme, Philip" uniqKey="Van Damme P" first="Philip" last="Van Damme">Philip Van Damme</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Fernandez Antiago, Ruben" sort="Fernandez Antiago, Ruben" uniqKey="Fernandez Antiago R" first="Rubén" last="Fernández-Santiago">Rubén Fernández-Santiago</name></region></country><country name="Suisse"><noRegion><name sortKey="Weber, Markus" sort="Weber, Markus" uniqKey="Weber M" first="Markus" last="Weber">Markus Weber</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000397 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000397 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1104402D2CD5B78610B101FB2326A7D93EC038A3
|texte= Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis
}}
| This area was generated with Dilib version V0.6.23. |  |